May be history of tsetse fly bite and swelling at site of bite after 7-14 days (more often in T. rhodesiense, rarely in T. Gambiense)}<b>T. Rhodesiense</b><br>yy Incubation is 2-3 weeks yy Early stage (haemolymphatic stage): headache not responding to common analgesics, fever, generalised lymphadenopathy, joint pains yy Late stage (meningoencephalitis stage): after some weeks, neurological and psychiatric symptoms like apathy, day sleepiness, paralysis, seizures yy If not treated: cachexia, lethargy, coma and death within 3-6 months}<b>T. gambiense</b><br>yy Similar to the rhodesiense but less acute and with slower progression yy Incubation can last several years