<b>Treatment of uncomplicated malaria</b><br><b>Dosage of artemether/lumefantrine 20/120 mg</b><br><b>WEIGHT (KG) 5–14</b> 4 months– 3 years, DAY 1-1 tab twice daily, DAY 2-1 tab twice daily, DAY 3-1 tab twice daily<br><b>WEIGHT (KG) 15–24</b> 3–7 years: DAY 1- 2 tab twice daily, DAY 2- 2 tab twice daily,, DAY 3- 2 tab twice daily<br><b>WEIGHT (KG) 15–24</b> 3–7 years: DAY 1- 2 tab twice daily, DAY 2- 2 tab twice daily,, DAY 3- 2 tab twice daily<br><b>WEIGHT (KG) 15–24</b> 3–7 years: DAY 1- 2 tab twice daily, DAY 2- 2 tab twice daily, DAY 3- 2 tab twice daily<br><b>WEIGHT (KG) 25–34</b> 7–12 years: DAY 1- 3 tab twice daily, DAY 2- 3 tab twice daily, DAY 3- 3 tab twice daily<br><b>WEIGHT (KG) >35</b> > 12 years: DAY 1- 4 tab twice daily, DAY 2- 4 tab twice daily, DAY 3- 4 tab twice daily <br><b><i>Note: Give doses every 12 hours</i></b>}<b>Treatment of uncomplicated malaria</b><br><b>Dosage of artesunate (AS) tablets 50 mg once a day</b><br><b> 5 - 11 months</b>, DAY 1- 25 mg (½ tab), DAY 2- 25 mg (½ tab), DAY 3-  25 mg (½ tab)<br><b> 1–6 years</b>, DAY 1- 50mg (1 tab), DAY 2- 50mg (1 tab), DAY 3-  50mg (1 tab)<br><b> 7–13 years:</b> DAY 1- 100mg (2 tab), DAY 2- 100mg (2 tab), DAY 3- 100mg (2 tab)<br><b> >13 years:</b> DAY 1- 200 mg (4 tabs), DAY 2- 200 mg (4 tabs), DAY 3- 200 mg (4 tabs)<br><b><i>Note: Do not use artesunate alone, give with amodiaquine tabs</i></b>}<b>Treatment of uncomplicated malaria</b><br><b>Dosage of amodiaquine (AQ) 153 mg tablets</b><br><b> 5 - 11 months</b>, DAY 1- 76mg (½ tab), DAY 2- 76mg (½ tab), DAY 3-  76mg (½ tab)<br><b> 1–6 years</b>, DAY 1- 153mg (1 tab), DAY 2- 153mg (1 tab), DAY 3-  153mg (1 tab)<br><b> 7–13 years:</b> DAY 1- 306mg (2 tab), DAY 2- 306mg (2 tab), DAY 3- 306mg (2 tab)<br><b> >13 years:</b> DAY 1- 612 mg (4 tabs), DAY 2- 612 mg (4 tabs), DAY 3- 612 mg (4 tabs)<br><b><i>Note: Do not use amodiaquine alone, use with artesunate tabs</i></b>}<b>Treatment of uncomplicated malaria</b><br><b>Dosage of dihydroartemisinin (DHA)/Piperaquine tablets (PPQ) (40/320 mg) tablets</b><br><b>WEIGHT (KG) 5–9.9</b> 6 months– 1 year, DAY 1- 0.5, DAY 2- 0.5, DAY 3- 0.5<br><b>WEIGHT (KG) 10–20</b> 2–7 years: DAY 1- 1, DAY 2- 1, DAY 3- 1<br><b>WEIGHT (KG) 20–40</b> 8–13 years: DAY 1- 2, DAY 2- 2, DAY 3- 2<br><b>WEIGHT (KG) >40</b> >14 years: DAY 1- 3, DAY 2- 3, DAY 3- 3<br>}<b>Treatment of uncomplicated malaria</b><br><b>Dosage of quinine tablets (1 quinine tab = 300 mg salt)</b><br><b>WEIGHT (KG) 5–10</b> 3 months– 1 year, 75 mg (¼ tab) DOSE (TO BE GIVEN EVERY 8 HOURS FOR 7 DAYS)<br><b>WEIGHT (KG) 10–18</b> 1–5 years: 150 mg (½ tab) DOSE (TO BE GIVEN EVERY 8 HOURS FOR 7 DAYS)<br><b>WEIGHT (KG) 18–24</b> 5–7 years: 225 mg (¾ tab)DOSE (TO BE GIVEN EVERY 8 HOURS FOR 7 DAYS)<br><b>WEIGHT (KG) 24–30</b>7–10 years: 300 mg (1 tab)DOSE (TO BE GIVEN EVERY 8 HOURS FOR 7 DAYS)<br><b>WEIGHT (KG) 30–40</b> 10–13 years: 375 mg (1¼ tab)DOSE (TO BE GIVEN EVERY 8 HOURS FOR 7 DAYS)<br><b>WEIGHT (KG) 40–50</b> 13–15 years: 450 mg (1½ tab) DOSE (TO BE GIVEN EVERY 8 HOURS FOR 7 DAYS)<br><b>WEIGHT (KG) >50</b> >15 years: 600 (2 tabs) DOSE (TO BE GIVEN EVERY 8 HOURS FOR 7 DAYS)<br>}<b>Treatment of severe malaria</b><br><b>Dosage of rectal artesunate in children</b><br><b>WEIGHT (KG) <6</b> 2 - 4months, 50 mg, 1 supp (50 mg) REGIMEN (SINGLE DOSE)<br><b>WEIGHT (KG) 6–11.9 </b> 4 months- 2 years, 100 mg, 2 supp (50 mg) REGIMEN (SINGLE DOSE)<br><b>WEIGHT (KG) 12–19 </b> 2–5 years, 150 mg, 3 supp (50 mg) REGIMEN (SINGLE DOSE)<br><b>WEIGHT (KG) 20–29 </b> 6–10 years, 200 mg, 1 supp (200 mg) REGIMEN (SINGLE DOSE)<br><b>WEIGHT (KG) 30–39 </b> 10–13 years, 300 mg, 1 supp (200 mg) + 2 supp (50 mg) REGIMEN (SINGLE DOSE)<br>}<b>Treatment of uncomplicated malaria</b><br><b>Dosage of rectal artesunate in adults</b><br><b>WEIGHT (KG) < 40 </b> 10 mg/kg bodyweight Use appropriate number of rectal supp<br><b>WEIGHT (KG) 40–59 </b> 400 mg,  2 supp of 200 mgREGIMEN (SINGLE DOSE)<br><b>WEIGHT (KG) < 40 </b> 10 mg/kg bodyweight Use appropriate number of rectal supp<br><b>WEIGHT (KG) 40–59 </b> 400 mg,  2 supp of 200 mg, REGIMEN (SINGLE DOSE)<br><b>WEIGHT (KG) 60–80 </b> 800 mg, 4 supp of 200 mg, REGIMEN (SINGLE DOSE)<br><b>WEIGHT (KG) > 80 </b> 1200 mg, 6 supp of 200 mg, REGIMEN (SINGLE DOSE)}<b>Preparation of IV or IM artesunate</b><br>yy IV artesunate is usually dispensed in powder vial of 60 mg, pre-packed with sodium bicarbonate solution 1 ml yy Calculate the dose in mg according to the weight and the number of vials needed yy Reconstitute each vial separately, and use within 1 hour yy Reconstitution: inject all the content of the bicarbonate ampoule (1 ml) in the artesunate vial. Shake gently till solution become clear (discard if not clear after 2 minutes)}<b>IV use</b><br>yy Dilution: dilute solution by adding 5 ml of sodium chloride 0.9% (normal saline) or Dextrose 5%, obtaining a concentration of 10 mg/ml yy Calculate the required volume and withdraw yy Give by IV injection slowly over 5 minutes}<b>IM use</b><br>yy Dilution: dilute solution by adding 2 ml of sodium chloride 0.9%, obtaining a concentration of 20 mg/ml –– Inject into the upper outer anterior thigh, NEVER in the buttock DO NOT USE WATER FOR INJECTION FOR DILUTION}<b>Dosage of IM artemether</b><br> First dose: on admission Loading dose - At 0 hours - QUANTITY : 3.2 mg/kg<br>Second dose - At 24 hours - QUANTITY : 1.6 mg/kg<br>Third dose - At 48 hours - QUANTITY : 1.6 mg/kg<br>Then once a day until patient is able to tolerate oral medication, then give a full course of oral ACT}<b>Dosage of quinine IV</b>ff10 mg/kg in dextrose 5% every 8 hours till patient is able to tolerate oral medication ffThen complete with a full dose of ACT (3 days) or quinine tablets to complete 7 days