<b>Early (first) stage T. rhodesiense sleeping sickness</b><br> For both children and adults ffSuramin IV –– A test dose of 5 mg/kg of body weight should first be administered to test for anaphylactic reaction –– Followed by five injections of 20 mg/kg every 5 days interval Day 0: 5 mg/kg body weight Day 3: 20 mg/kg body weight Day 8: 20 mg/kg body weight Day 13: 20 mg/kg body weight Day 18: 20 mg/kg body weight Day 23: 20 mg/kg body weight If anaphylaxis: do not administer}<b>T. gambiense sleeping sickness</b><br>For both children and adults ffPentamidine IM 4 mg/kg daily for 7 days –– Give food 1 hour before to prevent hypoglycaemia –– The patient should be in a supine position during administration and 1 hour after to prevent hypotension}<b>Late (second) stage T. rhodesiense sleeping sickness</b><br>For both children and adults ffIV Melarsoprol 2.2 mg/kg body weight daily for 10 days}<b>Late (second) stage T.gambiense sleeping sickness Children ≤ 12 years and <35 kg</b>ffEflornithine IV 150 mg/kg 6 hourly for 14 days (total dose of 600 mg/kg/day. Dilute 150 mg/kg dose of eflornithine into the 100 ml of distilled water. Administer the infusion over at least 2 hours}<b>Late (second) stage Children >12 years up to 15 years</b><br>ffEflornithine IV 100 mg/kg 6 hourly for 14 days (total dose of 400 mg/kg per day). Dilute the eflornithine dose of 100 mg/kg into the 100 ml of distilled water. Administer the infusion over at least 2 hours (rate 20 drops/minute)}<b>Late (second) stage Adults >15 years</b><br>–– Nifurtimox/Elfornithine combination therapy (NECT) –– Nifurtimox: 5 mg/kg every 8 hours orally for 10 days (15 mg/kg/day) –– Plus Eflornithine 200 mg/kg 12 hourly for 7 days (400 mg/kg/day). Dilute Eflornithine dose of 200 mg/kg into 250 ml of distilled water and administer the infusion over at least 2 hours (50 drops/minute) –– Infusions are given slowly to prevent convulsions}<b>Relapses</b><br>ffIV melarsoprol 2.2 mg/kg once daily for 10 days