<b>Refer to hospital after initial dose of antibiotics Supportive care</b><br>ffKeep baby warm ffFor high temperature control environment (undress), avoid paracetamol ffPrevent hypoglycaemia (breastfeeding if tolerated/possible, NGT or IV glucose) ffEnsure hydration/nutrition ffGive oxygen if needed (SpO2 <92%)}<b>Empirical regimen (for 21 days)</b><br>ffAmpicillin IV Neonate < 7 days: 50-100 mg/kg every 12 hours Neonate > 7 days: 50-100 mg/kg every 8 hours ffPlus Gentamicin 2.5 mg/kg IV every 12 hours}<b>If group B streptococci</b><br>ffBenzylpenicillin 100,000-150,000 IU/kg IV every 4-6 hours Neonates <7 days: 50,000-100,000 IU/kg IV every 8 hours ffPlus gentamicin 2.5 mg/kg IV every 12 hours ffContinue treatment for a total of 3 weeks}<b>Cryptococcal Meningitis: Fungal meningitis caused by Crypotococcus neoformans and usually occurs in severely immunosuppressed patients (e.g. advanced HIV, usually CD4 < 100). yy It commonly presents with headache, fever, malaise developing over 1 or 2 weeks, progressing into confusion, photophobia, stiff neck ¾¾Diagnosis is through identification of the microorganism in the CSF with Indian Ink stain, antigen in CSF or culture</b><br>ffRefer to hospital}<b>TB Meningitis</b><br>Meningitis caused by M. tuberculosis. Onset may be gradual with fatigue, fever, vomiting, weight loss, irritability, headache, progressing to confusion, focal neurological deficits, meningeal irritation, till coma. ¾¾For diagnosis: check CSF (raised protein, lymphocytosis), look for possible primary TB site<br>ffRefer to hospital ffTreat as per pulmonary TB but continuation phase is 10 months instead of 4 (2RHZE/10RH)